Jorge Isaacs Ferrer (April 1, 1837 – April 17, 1895) was a Colombian writer, politician and soldier. His only novel, María, became one of the most notable works of the Romantic movement in Spanish-language literature.

His father was George Henry Isaacs, an English Jew originally from Jamaica. He first settled in Chocó, Colombia, where he made a fortune from gold mining and trade with the Caribbean. He then moved to Cali where he applied for his Colombian citizenship from Simon Bolivar and paid for it in cows. (There is a plaque on a bridge north of Bogota to commemorate this) He married Manuela Ferrer Scarpetta, daughter of a Spanish Navy officer. He also owned two haciendas near Cali, called "La Manuelita" (named after his wife) and "El Paraíso". The latter would provide the setting for María. "El Paraiso" has been preserved as a museum, with emphasis upon its relation to the novel.

When María was published in 1867 it became an immediate success both in Colombia and in other Latin American countries. As a consequence Isaacs became a well-known personality in Colombia and his newly found fame allowed him to start a career as journalist and politician. As a journalist he directed the newspaper La República, of moderate conservative tendencies, in which he also published some articles. As a politician he first joined the Conservative Party, but later switched to the Radical Party. In 1870 he was sent to Chile as consul general. On his return to Colombia he was actively involved in the politics of Valle del Cauca, which he represented in the Colombian Congress, and in 1876 he fought in yet another civil war. However his political career ended in 1879 after an incident where he proclaimed himself political and military leader of Antioquia in response to a conservative revolt.

After his retirement from politics Isaacs published in 1881 the first canto of the poem Saulo, although he was never able to complete it. He also explored the Magdalena Department, in the north of Colombia, where he found important coal and oil deposits. Isaacs spent the last years of his life in the city of Ibagué in Tolima where was planning to write a historical novel. He died of malaria on April 17, 1895.