Andrew Karpen (April 18, 1966 – April 28, 2025) was an American independent film executive and producer. He was the founder and CEO of Bleecker Street. He was previously the co-CEO of Focus Features. He was an executive producer for the films Denial (2016), The Man Who Invented Christmas (2017), The Last Word (2017), The Art of Self-Defense (2019), Golda (2023), The Return (2024), and Hard Truths (2024).

Karpen died of glioblastoma in Fairfield County, Connecticut, on April 28, 2025, at the age of 59.

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