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Sisse Marie Holzmann Søby (born 21 November 1985) is a Danish singer, model, TV hostess and songwriter.

She was born in Aalborg. In 2001 she won the most prestigious song contest for young people on Danish national television, which led to a gold certified album. The following year she received a Grammy for Best Teen Album. Since then, she worked as a model in Milan, London, Atlanta, Copenhagen, Oslo, Munich, Amsterdam, Istanbul and Stockholm. She has done model photos, catalogues and billboards for Tiffany Bridal, O'Neill, Heineken, Volvo, Citroën and Wonderbra. She has done photo series and covers of Cosmopolitan, T3, Ché and Marie Claire and runway for Italian Vogue.

In 2005 she released the single "Boom", which went in at No. 4 on the official Danish single chart. The following year she began as a hostess at the Danish MTV, and made the subsequent two seasons. Her program was MTV's most watched.

On 25 October 2010 she released the now gold certified single "Every Time (You Look at Me)". The song went straight to number 1 in Denmark and the music video was on the release day the 8th most watched on YouTube in the world. On 9 May 2011 she released the single "Dirty Hands" which went No. 1 on MTV Denmark and Brazil. 19 February she released the single "Kill for Your Love" which went No. 1 on MTV Denmark and on the national TV-channel DR MAMA.

On 15 November 2012 Sisse Marie had her song "Paralyzed" featured in the best selling video game of all time The Sims. She was also designed as a digital character in the game. The game has sold more than 150 million copies worldwide.