Jessica Castello was born in Santa Monica, California. She is of Italian (father) and Welsh-English (mother) descent.

As a child, she was featured in national commercials for Burlington, Facebook and DISH Network. Jessica studied with John D'Aquino, Cynthia Bain and Kristopher Kyer in Los Angeles. Her theatrical resume includes Beauty & The Beast (Belle), The Little Mermaid (Aerial) and as a Singer/Soloist for the Cabrillo Teen Project at the Cabrillo Music Theater.

Jessica's films include starring roles in Before Summer (2016), I Feel Fine (2017) and Oildale (2019) in which she was named "Best Actress in a Feature Film" at the SENE Film Festival.