Uno Naissoo (March 25, 1928, Viljandi – January 5, 1980, Tallinn) was an Estonian composer and jazz musician.

In 1952, he graduated from Tallinn State Conservatory. Naissoo then taught music theory subjects at Georg Ots Tallinn Music School from 1952 to 1980.

He has also directed several ensembles, including Swing Club (1947–1957), Rütmikud (1948–1950). Naissoo has been a member of Estonian Composers' Union since 1954.

His son is pianist and composer Tõnu Naissoo